TOPCHeF | NHLBI Trans-Omics for Precision Medicine

Trans-Omics for Precision Medicine for Congestive Heart Failure

TOPCHeF

Progress Report

Status report for HCN4, NELFE, and NRG1 and reverse LV remodeling (Taylor)

Abstracts associated with this proposal

Rare variants affecting telomere length and disease identified through multi-omic modeling

Progress Report

Status report for Watershed multi-omics modeling to identify rare variants affecting telomere length (Prop ID:17322)

Progress Report

Status report for Assessing genetic determinants of telomere length leveraging whole genome sequence data in the NHLBI Trans-Omics for Precision Medicine Program – breakout proposal for PRS. (Prop ID:16887)

Progress Report

Status report for Patterns of ultra-rare genetic variation from high coverage whole genome sequencing of over 150,000 diverse people. (Prop ID:16344)

Progress Report

Status report for Prevalence and Association of Putative Pathogenic Genetic Variants Predisposing to Inherited Cardiomyopathies in a Multi-Ethnic Population (Prop ID:14647)

Progress Report

Status report for Genome-Wide Association Study of Natriuretic Peptides and its Association with Cardiometabolic Traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program (Prop ID:14442)

Abstracts associated with this proposal

Unveiling the Hidden Rules: Enhancing NMD Prediction for Protein-Truncating Variants

Progress Report

Status report for Systematic profiling and characterization of transcripts that are associated with quantitative blood disease traits through putative gain-of-function variants (Prop ID:14437)

Abstracts associated with this proposal

Cross-cohort eQTL analyses of 6,602 multi-ancestry TOPMed whole blood RNA-seq samples uncover regulatory relationships

Cross-cohort eQTL fine-mapping utilizing TOPMed whole genome sequencing identifies tens of thousands of independent eQTLs signals and thousands of eQTLs colocalizing with complex trait-associated variants

Progress Report

Status report for Cross-cohort RNA-seq harmonization and analysis of expression and splicing quantitative trait loci in TOPMed (Prop ID:11806)

Progress Report

Status report for Meta-analysis of genetic association studies for clonal hematopoiesis (Prop ID:11420)