Genetic Epidemiology of COPD

Short Name	COPD
Institution(s)	Brigham & Women's Hospital
Type of Omics	WGS RNASeq Methylomics
Approx. Sample Size	100WGS EOCOPD (ph1), 1885WGS COPDGene (ph1), 7400WGS (ph2), 1000WGS COPDGene (ph3), 800RNASeq COPDGene (ph4), 11,500Methyl COPDGene (ph5)
Disease/Phenotype	Genetic risk and protective variants in COPD in African American and European American populations
Starting Phase	Phase 1
dbGaP ID	phs000951 phs000946
TOPMed Accession #	Please see this TOPMed Project's Parent Studies.
Omics Center(s) Phase 1	Northwest Genomics Center
Omics Center(s) Phase 2	Broad Institute Genomics Platform
Omics Center(s) Phase 3	Broad Institute Genomics Platform
Omics Center(s) Phase 4	Northwest Genomics Center
Omics Center(s) Phase 5	Northwest Genomics Center
Phases Involved	1 2 3 4 5 Other Funding
Populations	African American (30%)
PI	Ed Silverman
Contact	Ed Silverman
NIH Program Officer	Weiniu Gan
Phenotype Liaison	Michael Cho Carla Wilson
Steering Committee Representatives	Terri Beaty Ed Silverman
P&P primary	John Hokanson
P&P alternate	Terri Beaty
Project	COPD

WGS Released

10825

WGS Subjects

10677

Methylation Released

12215

Methylation Subjects

7357

RNA-seq Released

723

RNA-seq Subjects

386

Metabolomics Released

9141

Metabolomics Subjects

6607

Released

Yes