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Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

Manuscript ID: 12796

Submitting Author
Li, Xihao
Submitting Author's Email
xihaoli@g.harvard.edu
Authors
Xihao Li, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor, Yaowu Liu, Han Chen, Margaret S. Selvaraj, Ryan Sun, Rounak Dey, Donna K. Arnett, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Paul S. de Vries, Ravindranath Duggirala, Barry I. Freedman, Harald H. H. Göring, Xiuqing Guo, Jeffrey Haessler, Rita R. Kalyani, Charles Kooperberg, Brian G. Kral, Leslie A. Lange, Ani Manichaikul, Lisa W. Martin, Stephen T. McGarvey, Braxton D. Mitchell, May E. Montasser, Alanna C. Morrison, Take Naseri, Jeffrey R. O’Connell, Nicholette D. Palmer, Patricia A. Peyser, Bruce M. Psaty, Laura M. Raffield, Susan Redline, Alexander P. Reiner, Muagututi‘a Sefuiva Reupena, Kenneth M. Rice, Stephen S. Rich, Colleen M. Sitlani, Jennifer A. Smith, Kent D. Taylor, Ramachandran S. Vasan, James G. Wilson, Lisa R. Yanek, Wei Zhao, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Jerome I. Rotter, Christen J. Willer, Pradeep Natarajan, Gina M. Peloso, Zilin Li, and Xihong Lin
Journal name for most current submission
Nature Genetics
Associated TOPMed paper proposal
Powerful and resource-efficient rare variant meta-analysis for large-scale whole genome sequencing studies using summary statistics and functional annotations, with application to TOPMed lipid data
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" *
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments
I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. *
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. *
Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. *
Yes
I certify that all co-authors have reviewed and approved the manuscript for submission. *
Yes
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.

TOPMed data used in this manuscript

The data set approvals listed here should match the TOPMed data used in this manuscript.

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Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.

Parent Study: Consent Group Review Status Actions
ARIC:DS-CVD-IRB Approved automatically after 2 weeks
ARIC:HMB-IRB Approved automatically after 2 weeks
Amish:HMB-IRB-MDS Approved automatically after 2 weeks
CFS:DS-HLBS-IRB-NPU Approved automatically after 2 weeks
CHS:DS-CVD-MDS Approved
CHS:DS-CVD-NPU-MDS Approved
CHS:HMB-MDS Approved
CHS:HMB-NPU-MDS Approved
DHS:DS-DHD-IRB-COL-NPU Approved
DHS:HMB-IRB-COL-NPU Approved
FHS:HMB-IRB-MDS Approved automatically after 2 weeks
FHS:HMB-IRB-NPU-MDS Approved automatically after 2 weeks
GENOA:DS-ASC-RF-NPU Approved
GOLDN:DS-CVD-IRB Approved automatically after 2 weeks
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
JHS:DS-FDO-IRB Approved
JHS:DS-FDO-IRB-NPU Approved
JHS:HMB-IRB Approved
JHS:HMB-IRB-NPU Approved
MESA:HMB Approved
MESA:HMB-NPU Approved
SAFS:DS-DHD-IRB-PUB-MDS-RD Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO Approved
WHI:HMB-IRB Approved
WHI:HMB-IRB-NPU Approved