Rare coding variants in RCN3 are associated with blood pressure

Karen Y. He, PhD[1], Tanika N. Kelly, PhD, MPH[2], Heming Wang, PhD[1, 3, 4], Jingjing Liang, PhD[1], Luke Zhu, BS[5], Brian E. Cade, PhD[3, 6], Themistocles L. Assimes, MD, PhD[7], Lewis C. Becker, MD[8], Amber L. Beitelshees, PharmD, MPH[9], Lawrence F. Bielak, DDS, MPH[10], Adam P. Bress, PharmD, MS[11], Jennifer A. Brody, BA[12], Yen-Pei Christy Chang, PhD[9], Yi-Cheng Chang, MD, PhD[13-15], Paul S. de Vries, PhD[16], Ravindranath Duggirala, PhD[17], Ervin R. Fox, MD[18], Nora Franceschini, MD, MPH[19], Anna L. Furniss, BS[20], Yan Gao, MS [21], Xiuqing Guo, PhD[22], Jeffrey Haessler, MS [23], Yi-Jen Hung, MD[24], Shih-Jen Hwang, PhD[25], Marguerite Ryan Irvin, PhD, MS[26], Rita R. Kalyani, MD, MHS[27], Ching-Ti Liu, PhD [25], Chunyu Liu, PhD[25], Lisa Warsinger Martin, MD[28], May E. Montasser, PhD, MS[9], Paul M. Muntner, PhD[26], Stanford Mwasongwe, MPH, Mdiv[29], Take Naseri, MD, MPH[30], Walter Palmas, MD[31], Muagututi‘a Sefuiva Reupena, MA[32], Kenneth M. Rice, PhD[33], Wayne H-H Sheu, MD, PhD[34], Daichi Shimbo, MD[31], Jennifer A. Smith, PhD, MPH, MA[10, 35], Beverly Snively, PhD[36], Lisa R. Yanek, MPH[37], Wei Zhao, PhD[10], John Blangero, PhD[17], Eric Boerwinkle, PhD[16, 38], Yii-Der Ida Chen, PhD[22, 39], Adolfo Correa, MD, PhD[20], L. Adrienne Cupples, PhD[25], Joanne E. Curran, PhD[17], Myriam Fornage, PhD[40, 41], Jiang He, MD, PhD[2], Lifang Hou, MD, MS, PhD[42], Robert C. Kaplan, PhD[43], Sharon L. R. Kardia, PhD[10], Eimear Kenny, PhD[44], Charles Kooperberg, PhD[23], Donald Lloyd-Jones, MD[42], Ruth J. F. Loos, PhD[45], Rasika A. Mathias, ScD[46], Stephen T. McGarvey, PhD, MPH[47, 48], Braxton D. Mitchell, PhD, MPH[9, 49], Kari E. North, PhD[19, 50], Patricia A. Peyser, PhD[10], Bruce M. Psaty, MD, PhD[51], Laura Raffield, PhD[50], DC Rao, PhD[52], Susan Redline, MD, MPH[3, 6, 53], Alex P. Reiner, MD[54], Stephen S. Rich, PhD[55], Jerome I. Rotter, MD[22], Kent D. Taylor, PhD[22], Russell Tracy, PhD[56, 57], Ramachandran S. Vasan, MD[25], The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group[58], NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Blood Pressure Working Group, Alanna C. Morrison, PhD[16], Daniel Levy, MD[25, 59], Aravinda Chakravarti, PhD[5], Donna K. Arnett, PhD[60], Xiaofeng Zhu, PhD[1]*

1. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
2. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
3. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA, USA.
4. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
5. Center for Human Genetics & Genomics, Department of Medicine, New York University Langone Health, New York, NY, USA.
6. Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
7. Department of Medicine, Stanford University, Palo Alto, CA, USA.
8. GeneSTAR Research Program, Department of Medicine, Divisions of Cardiology and General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
9. Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
10. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
11. Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
12. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
13. Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei City, Taiwan.
14. Institute of Biomedical Sciences, Academia Sinica, Taipei City, Taiwan.
15. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
16. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
17. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
18. Division of Cardiovascular Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
19. Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.
20. Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
21. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
22. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
23. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
24. Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan.
25. Boston University’s and National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA, USA.
26. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AB, USA.
27. GeneSTAR Research Program, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
28. Division of Cardiology, Department of Medicine, George Washington University, Washington, DC, USA.
29. Jackson Heart Study, Jackson State University, Jackson, MS, USA.
30. Ministry of Health, Government of Samoa, Apia, Samoa.
31. Division of General Medicine, Columbia University Medical Center, New York, NY, USA.
32. Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa.
33. Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
34. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
35. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
36. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
37. GeneSTAR Research Program, Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
38. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
39. Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center Professor of Pediatrics, UCLA, Torrance, CA, USA.
40. Center for Human Genetics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
41. Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
42. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, USA.
43. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA.
44. Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
45. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
46. GeneSTAR Research Program, Department of Medicine, Divisions of Allergy and Clinical Immunology and General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
47. International Health Institute and Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
48. Department of Anthropology, Brown University, Providence, Rhode Island, USA.
49. Geriatrics Research and Education Clinical Center, Veterans Affairs Medical Center, Baltimore, MD, USA.
50. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
51. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
52. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
53. Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
54. Department of Epidemiology, University of Washington, Seattle, WA, USA.
55. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
56. Department of Pathology & Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
57. Department of Biochemistry, University of Vermont, Burlington, VT, USA.
58. Ranjan Deka, Dept. of Environmental Health, University of Cincinnati; Nicola L. Hawley, Dept. of Chronic Disease Epidemiology, Yale University; Stephen T McGarvey, Dept. of Epidemiology and International Health Institute, and Dept. of Anthropology, Brown University; Ryan L Minster, Dept. of Human Genetics, University of Pittsburgh; Take Naseri, Ministry of Health, Government of Samoa; Muagututi‘a Sefuiva Reupena, Lutia I Puava Ae Mapu I Fagalele; Daniel E. Weeks, Depts. of Human Genetics and Biostatistics, University of Pittsburgh.
59. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
60. University of Kentucky College of Public Health, Lexington, KY, USA.