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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Manuscript ID: 6429

Submitting Author
Taliun, Daniel
Submitting Author's Email
dtaliun@umich.edu
Authors
Daniel Taliun,
Daniel N. Harris,
Michael D. Kessler,
Jedidiah Carlson,
Zachary A. Szpiech,
Raul Torres,
Sarah A. Gagliano Taliun,
André Corvelo,
Stephanie M. Gogarten,
Hyun Min Kang,
Achilleas N. Pitsillides,
Jonathon LeFaive,
Seung-been Lee,
Xiaowen Tian,
Brian L. Browning,
Sayantan Das,
Anne-Katrin Emde,
Wayne E. Clarke,
Douglas P. Loesch,
Amol C. Shetty,
Thomas W. Blackwell,
Quenna Wong,
François Aguet,
Christine Albert,
Alvaro Alonso,
Kristin G. Ardlie,
Stella Aslibekyan,
Paul L. Auer,
John Barnard,
R. Graham Barr,
Lewis C. Becker,
Rebecca L. Beer,
Emelia J. Benjamin,
Lawrence F. Bielak,
John Blangero,
Michael Boehnke,
Donald W. Bowden,
Jennifer A. Brody,
Esteban G. Burchard,
Brian E. Cade,
James F. Casella,
Brandon Chalazan,
Yii-Der Ida Chen,
Michael H. Cho,
Seung Hoan Choi,
Mina K. Chung,
Clary B. Clish,
Adolfo Correa,
Joanne E. Curran,
Brian Custer,
Dawood Darbar,
Michelle Daya,
Mariza de Andrade,
Dawn L. DeMeo,
Susan K. Dutcher,
Patrick T. Ellinor,
Leslie S. Emery,
Diane Fatkin,
Lukas Forer,
Myriam Fornage,
Nora Franceschini,
Christian Fuchsberger,
Stephanie M. Fullerton,
Soren Germer,
Mark T. Gladwin,
Daniel J. Gottlieb,
Xiuqing Guo,
Michael E. Hall,
Jiang He,
Nancy L. Heard-Costa,
Susan R. Heckbert,
Marguerite R. Irvin,
Jill M. Johnsen,
Andrew D. Johnson,
Sharon L.R. Kardia,
Tanika Kelly,
Shannon Kelly,
Eimear E. Kenny,
Douglas P. Kiel,
Robert Klemmer,
Barbara A. Konkle,
Charles Kooperberg,
Anna Köttgen,
Leslie A. Lange,
Jessica Lasky-Su,
Daniel Levy,
Xihong Lin,
Keng-Han Lin,
Chunyu Liu,
Ruth J.F. Loos,
Lori Garman,
Robert Gerszten,
Steven A. Lubitz,
Kathryn L. Lunetta,
Angel C.Y. Mak,
Ani Manichaikul,
Alisa K. Manning,
Rasika A. Mathias,
David D. McManus,
Stephen T. McGarvey,
James B. Meigs,
Deborah A. Meyers,
Julie L. Mikulla,
Mollie A. Minear,
Braxton Mitchell,
Sanghamitra Mohanty,
May E. Montasser,
Courtney Montgomery,
Alanna C. Morrison,
Joanne M. Murabito,
Andrea Natale,
Pradeep Natarajan,
Sarah C. Nelson,
Kari E. North,
Jeffrey R. O'Connell,
Nicholette D. Palmer,
Nathan Pankratz,
Gina M. Peloso,
Patricia A. Peyser,
Wendy S. Post,
Bruce M. Psaty,
D.C. Rao,
Susan Redline,
Alexander P. Reiner,
Dan Roden,
Jerome I. Rotter,
Ingo Ruczinski,
Chloé Sarnowski,
Sebastian Schoenherr,
Jeong-Sun Seo,
Sudha Seshadri,
Vivien A. Sheehan,
M. Benjamin Shoemaker,
Albert V. Smith,
Nicholas L. Smith,
Jennifer A. Smith,
Nona Sotoodehnia,
Adrienne M. Stilp,
Weihong Tang,
Kent D. Taylor,
Marilyn Telen,
Timothy A. Thornton,
Russell P. Tracy,
David J. Van Den Berg,
Ramachandran S. Vasan,
Karine A. Viaud-Martinez,
Scott Vrieze,
Daniel E Weeks,
Bruce S. Weir,
Scott T. Weiss,
Lu-Chen Weng,
Cristen J. Willer,
Yingze Zhang,
Xutong Zhao,
Donna K. Arnett,
Allison E. Ashley-Koch,
Kathleen C. Barnes,
Eric Boerwinkle,
Stacey Gabriel,
Richard Gibbs,
Kenneth M. Rice,
Stephen S. Rich,
Edwin Silverman,
Pankaj Qasba,
Weiniu Gan,
George J. Papanicolaou,
Deborah A. Nickerson,
Sharon R. Browning,
Michael C. Zody,
Sebastian Zöllner,
James G. Wilson,
L Adrienne Cupples,
Cathy C. Laurie,
Cashell E. Jaquish,
Ryan D. Hernandez,
Timothy D. O'Connor,
Gonçalo R. Abecasis
Journal name for most current submission
Nature
Associated TOPMed paper proposal
The NHLBI Trans-Omics for Precision Medicine (TOPMed) Program
Sequencing of 55,000 human genomes (Part 1: general material)
Sequencing of 55,000 human genomes (Part 2: population genetics)
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" *
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments
I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. *
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. *
Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. *
Yes
I certify that all co-authors have reviewed and approved the manuscript for submission. *
Yes
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I have not
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I have not
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
I have not

TOPMed data used in this manuscript

The data set approvals listed here should match the TOPMed data used in this manuscript.

Don't see all the data sets you need? Request more data sets at any time.

Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.

Parent Study: Consent Group Review Status Actions
ARIC:DS-CVD-IRB Approved automatically after 2 weeks
ARIC:DS-CVD-IRB Approved
ARIC:DS-CVD-IRB Approved
ARIC:HMB-IRB Approved automatically after 2 weeks
ARIC:HMB-IRB Approved
ARIC:HMB-IRB Approved
Amish:HMB-IRB-MDS Approved
Amish:HMB-IRB-MDS Approved
Amish:HMB-IRB-MDS Approved
AustralianFamilialAF:HMB-NPU-MDS Approved
BAGS:GRU-IRB Approved
BAGS:GRU-IRB Approved
BAGS:GRU-IRB Approved
BioMe:GRU Request cancelled by original requester
BioMe:HMB-NPU Approved
CCAF:GRU-IRB Approved
CCAF:GRU-IRB Approved
CCAF:GRU-IRB Approved
CFS:DS-HLBS-IRB-NPU Approved automatically after 2 weeks
CFS:DS-HLBS-IRB-NPU Approved
CFS:DS-HLBS-IRB-NPU Approved
CHS:HMB-NPU-MDS Approved
CHS:HMB-NPU-MDS Approved
CHS:HMB-NPU-MDS Approved
COPDGene:DS-CS-RD Approved
COPDGene:DS-CS-RD Approved
COPDGene:DS-CS-RD Request cancelled by original requester
COPDGene:HMB Approved
COPDGene:HMB Approved
COPDGene:HMB Approved
CRA:DS-ASTHMA-IRB-MDS-RD Approved
CRA:DS-ASTHMA-IRB-MDS-RD Approved
CRA:DS-ASTHMA-IRB-MDS-RD Request cancelled by original requester
DECAF:GRU Approved
DHS:DS-DHD-IRB-COL-NPU Approved
DHS:DS-DHD-IRB-COL-NPU Approved
DHS:DS-DHD-IRB-COL-NPU Request cancelled by original requester
DHS:HMB-IRB-COL-NPU Approved
DHS:HMB-IRB-COL-NPU Approved
DHS:HMB-IRB-COL-NPU Request cancelled by original requester
EOCOPD:DS-CS-RD Approved
EOCOPD:DS-CS-RD Approved
EOCOPD:DS-CS-RD Request cancelled by original requester
FHS:HMB-IRB-MDS Approved
FHS:HMB-IRB-MDS Approved
FHS:HMB-IRB-MDS Approved
FHS:HMB-IRB-NPU-MDS Approved
FHS:HMB-IRB-NPU-MDS Approved
FHS:HMB-IRB-NPU-MDS Approved
GALAII:DS-LD-IRB-COL Approved
GALAII:DS-LD-IRB-COL Approved
GALAII:DS-LD-IRB-COL Approved
GENOA:DS-ASC-RF-NPU Approved
GENOA:DS-ASC-RF-NPU Approved
GENOA:DS-ASC-RF-NPU Approved
GOLDN:DS-CVD-IRB Approved
GOLDN:DS-CVD-IRB Approved
GOLDN:DS-CVD-IRB Approved
GenSalt:GRU-IRB Approved automatically after 2 weeks
GenSalt:GRU-IRB Approved automatically after 2 weeks
GenSalt:GRU-IRB Approved automatically after 2 weeks
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
HVH:DS-CVD-IRB-MDS Approved
HVH:DS-CVD-IRB-MDS Approved
HVH:DS-CVD-IRB-MDS Approved
HVH:HMB-IRB-MDS Approved
HVH:HMB-IRB-MDS Approved
HVH:HMB-IRB-MDS Approved
HyperGEN:DS-CVD-IRB-RD Approved
HyperGEN:DS-CVD-IRB-RD Approved
HyperGEN:DS-CVD-IRB-RD Approved
HyperGEN:GRU-IRB Approved
HyperGEN:GRU-IRB Approved
HyperGEN:GRU-IRB Approved
JHS:DS-FDO-IRB Approved
JHS:DS-FDO-IRB Approved
JHS:DS-FDO-IRB Approved
JHS:DS-FDO-IRB-NPU Approved
JHS:DS-FDO-IRB-NPU Approved
JHS:DS-FDO-IRB-NPU Approved
JHS:HMB-IRB Approved
JHS:HMB-IRB Approved
JHS:HMB-IRB Approved
JHS:HMB-IRB-NPU Approved
JHS:HMB-IRB-NPU Approved
JHS:HMB-IRB-NPU Approved
MESA:HMB Approved
MESA:HMB Approved
MESA:HMB Approved
MESA:HMB-NPU Approved
MESA:HMB-NPU Approved
MESA:HMB-NPU Approved
MGH_AF:DS-AF-IRB-RD Approved automatically after 2 weeks
MGH_AF:DS-AF-IRB-RD Approved
MGH_AF:DS-AF-IRB-RD Approved
MGH_AF:HMB-IRB Approved automatically after 2 weeks
MGH_AF:HMB-IRB Approved
MGH_AF:HMB-IRB Approved
MLOF:HMB-PUB Approved
Mayo_VTE:GRU Approved
Mayo_VTE:GRU Approved
Mayo_VTE:GRU Approved
OMG_SCD:DS-SCD-IRB-PUB-COL-MDS-RD Approved
Partners:HMB Approved automatically after 2 weeks
Partners:HMB Approved
Partners:HMB Approved
PharmHU:HMB Approved
REDS-III_Brazil:GRU-IRB-PUB-COL-NPU Approved
SAFS:DS-DHD-IRB-PUB-MDS-RD Approved
SAFS:DS-DHD-IRB-PUB-MDS-RD Approved
SAFS:DS-DHD-IRB-PUB-MDS-RD Approved
SAGE:DS-LD-IRB-COL Approved
SAGE:DS-LD-IRB-COL Approved
SAGE:DS-LD-IRB-COL Approved
SARP:GRU Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO Approved
Sarcoidosis:DS-SAR-IRB Approved
Sarcoidosis:DS-SAR-IRB Approved
Sarcoidosis:DS-SAR-IRB Approved
THRV:DS-CVD-IRB-COL-NPU-RD Approved automatically after 2 weeks
THRV:DS-CVD-IRB-COL-NPU-RD Approved
VAFAR:HMB-IRB Approved automatically after 2 weeks
VAFAR:HMB-IRB Approved
VAFAR:HMB-IRB Approved
VU_AF:GRU-IRB Approved
VU_AF:GRU-IRB Approved
VU_AF:GRU-IRB Approved
WGHS:HMB Approved automatically after 2 weeks
WGHS:HMB Approved
WGHS:HMB Approved
WHI:HMB-IRB Approved
WHI:HMB-IRB Approved
WHI:HMB-IRB Approved
WHI:HMB-IRB-NPU Approved
WHI:HMB-IRB-NPU Approved
WHI:HMB-IRB-NPU Approved
miRhythm:GRU Approved
walk_PHaSST:DS-SCD-IRB-PUB-COL-NPU-MDS-RD Approved
walk_PHaSST:HMB-IRB-PUB-COL-NPU-MDS-GSO Approved