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Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study

Submitting Author
Wang, Yuxuan
Submitting Author's Email
Authors
Yuxuan Wang, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Jacob A. Holdcraft, Donna K. Arnett, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Brian E. Cade, Jenna C. Carlson, April P. Carson, Yii-Der Ida Chen, Joanne E. Curran, Paul S. de Vries, Susan K. Dutcher, Patrick T. Ellinor, James S. Floyd, Myriam Fornage, Barry I. Freedman, Stacey Gabriel, Soren Germer, Richard A. Gibbs, Xiuqing Guo, Jiang He, Nancy Heard-Costa, Bertha Hildalgo, Lifang Hou, Marguerite R. Irvin, Roby Joehanes, Robert C. Kaplan, Sharon LR. Kardia, Tanika N. Kelly, Ryan Kim, Charles Kooperberg, Brian G. Kral, Daniel Levy, Changwei Li, Chunyu Liu, Don Lloyd-Jone, Ruth JF. Loos, Michael C. Mahaney, Lisa W. Martin, Rasika A. Mathias, Ryan L. Minster, Braxton D. Mitchell, May E. Montasser, Alanna C. Morrison, Joanne M. Murabito, Take Naseri, Jeffrey R. O'Connell, Nicholette D. Palmer, Michael H. Preuss, Bruce M. Psaty, Laura M. Raffield, Dabeeru C. Rao, Susan Redline, Alexander P. Reiner, Stephen S. Rich, Muagututi’a Sefuiva Ruepena, Wayne H-H. Sheu, Jennifer A. Smith, Albert Smith, Hemant K. Tiwari, Michael Y. Tsai, Karine A. Viaud-Martinez, Zhe Wang, Lisa R. Yanek, Wei Zhao, Jerome I. Rotter, Xihong Lin, Pradeep Natarajan, Gina M. Peloso
Journal name for most current submission
American Journal of Human Genetics
Associated TOPMed paper proposal
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments
I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable.
Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented.
Yes
I certify that all co-authors have reviewed and approved the manuscript for submission.
Yes
Upload all necessary study-specific approval documentation.
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.

TOPMed data used in this manuscript

The data set approvals listed here should match the TOPMed data used in this manuscript.

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Parent Study: Consent Group Review Status
ARIC:DS-CVD-IRB Approved automatically after 2 weeks
ARIC:HMB-IRB Approved automatically after 2 weeks
Amish:HMB-IRB-MDS Approved automatically after 2 weeks
BioMe:HMB-NPU Approved
CARDIA:HMB-IRB Approved automatically after 2 weeks
CARDIA:HMB-IRB-NPU Approved automatically after 2 weeks
CFS:DS-HLBS-IRB-NPU Approved automatically after 2 weeks
CHS:DS-CVD-MDS Approved
CHS:DS-CVD-NPU-MDS Approved
CHS:HMB-MDS Approved
CHS:HMB-NPU-MDS Approved
DHS:DS-DHD-IRB-COL-NPU Approved
DHS:HMB-IRB-COL-NPU Approved
FHS:HMB-IRB-MDS Approved
FHS:HMB-IRB-NPU-MDS Approved
GENOA:DS-ASC-RF-NPU Approved
GOLDN:DS-CVD-IRB Approved
GenSalt:DS-HCR-IRB Approved automatically after 2 weeks
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
HCHS_SOL:HMB Approved automatically after 2 weeks
HCHS_SOL:HMB-NPU Approved automatically after 2 weeks
HyperGEN:DS-CVD-IRB-RD Approved
HyperGEN:GRU-IRB Approved
JHS:DS-FDO-IRB Approved
JHS:DS-FDO-IRB-NPU Approved
JHS:HMB-IRB Approved
JHS:HMB-IRB-NPU Approved
MESA:HMB Approved
MESA:HMB-NPU Approved
MGH_AF:DS-AF-IRB-RD Approved automatically after 2 weeks
MGH_AF:HMB-IRB Approved automatically after 2 weeks
SAFS:DS-DHD-IRB-PUB-MDS-RD Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO Approved
THRV:DS-CVD-IRB-COL-NPU-RD Approved automatically after 2 weeks
WHI:HMB-IRB Approved
WHI:HMB-IRB-NPU Approved
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