The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
Manuscript ID: 12256
| Submitting Author |
Weinstock, Joshua
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|---|---|
| Submitting Author's Email | |
| Authors |
Joshua S. Weinstock1, Cecelia A. Laurie2, Jai G. Broome2,3, Kent D. Taylor4, Xiuqing Guo4, Alan R. Shuldiner5, Jeffrey R. O'Connell5, Joshua P. Lewis5, Eric Boerwinkle6, Kathleen C. Barnes7, Nathalie Chami8,9, Eimear E. Kenny10, Ruth J.F. Loos8,9, Myriam Fornage11, Susan Redline12,13, Brian E. Cade12,13,14, Frank D. Gilliland15, Zhanghua Chen15, W James. Gauderman15, Rajesh Kumar16,17, Leslie Grammer17, Robert P. Schleimer17, Bruce M. Psaty18,19,20, Joshua C. Bis18, Jennifer A. Brody18, Edwin K. Silverman21, Jeong H. Yun21, Dandi Qiao21, Scott T. Weiss22,12, Jessia Lasky-Su22,12, Dawn L. DeMeo22,12, Nicholette D. Palmer23, Barry I. Freedman24, Donald W. Bowden23, Michael H. Cho25, Ramachandran S. Vasan26, Andrew D. Johnson27, Rasika A. Mathias28, Lisa R. Yanek28, Lewis C. Becker28, Sharon Kardia29, Jiang He30, Robert Kaplan31, Susan R. Heckbert32,33, Nicholas L. Smith32,33,34, Kerri L. Wiggins35, Donna K. Arnett36, Marguerite R. Irvin R. Irvin37, Hemant Tiwari37, Adolfo Correa38, Laura M. Raffield39, Yan Gao40, Mariza de Andrade41, Jerome I. Rotter4, Stephen S. Rich42, Ani W. Manichaikul42, Barbara A. Konkle43, Jill M. Johnsen44,43, Marsha M. Wheeler45, Brian S. Custer46, Ravindranath Duggirala47,48, Joanne E. Curran47,48, John Blangero47,48, Hongsheng Gui49,50, Shujie Xiao49,50, L. Keoki Williams49,50, Deborah A. Meyers51, Xingnan Li52, Victor Ortega53, Stephen McGarvey54, C. Charles. Gu55, Yii-Der Ida. Chen56, Wen-Jane Lee57, M. Benjamin Shoemaker58, Dawood Darbar59, Dan Roden60, Christine Albert61, Charles Kooperberg62, Pinkal Desai63,64, Thomas W. Blackwell1, Goncalo R. Abecasis1,65, Albert V. Smith1, Hyun M. Kang1, Andrew Johnson27,66, Rasika Mathias28, Pradeep Natarajan67,14,68, Sidd Jaiswal69, Alexander P. Reiner62,70, Alexander G. Bick71 on behalf of the NHLBI Trans-Omics for Precision Medicine Consortium
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| Journal name for most current submission |
Sci Adv.
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| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" * |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
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| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
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| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. * |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
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| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. * |
Yes
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| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. * |
Yes
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| I certify that all co-authors have reviewed and approved the manuscript for submission. * |
Yes
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| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
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| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
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| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
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TOPMed data used in this manuscript
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| Parent Study: Consent Group | Review Status | Actions |
|---|---|---|
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks | |
| ARIC:HMB-IRB | Approved automatically after 2 weeks | |
| Amish:HMB-IRB-MDS | Approved automatically after 2 weeks | |
| BAGS:GRU-IRB | Approved | |
| BioMe:HMB-NPU | Approved | |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks | |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks | |
| CFS:DS-HLBS-IRB-NPU | Approved automatically after 2 weeks | |
| CHIRAH:DS-ASTHMA-IRB-COL | Approved automatically after 2 weeks | |
| CHS:DS-CVD-MDS | Approved | |
| CHS:DS-CVD-NPU-MDS | Approved | |
| CHS:HMB-MDS | Approved | |
| CHS:HMB-NPU-MDS | Approved | |
| COPDGene:DS-CS-RD | Approved | |
| COPDGene:HMB | Approved | |
| CRA:DS-ASTHMA-IRB-MDS-RD | Approved | |
| ChildrensHS_GAP:GRU | Disapproved | |
| ChildrensHS_IGERA:GRU | Disapproved | |
| ChildrensHS_MetaAir:GRU | Approved | |
| DHS:DS-DHD-IRB-COL-NPU | Approved | |
| DHS:HMB-IRB-COL-NPU | Approved | |
| ECLIPSE:DS-CS-MDS-RD | Approved | |
| EOCOPD:DS-CS-RD | Approved | |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks | |
| FHS:HMB-IRB-NPU-MDS | Approved automatically after 2 weeks | |
| GALAI:DS-LD-IRB-COL | Disapproved | |
| GALAII:DS-LD-IRB-COL | Disapproved | |
| GENOA:DS-ASC-RF-NPU | Approved | |
| GOLDN:DS-CVD-IRB | Approved | |
| GenSalt:DS-HCR-IRB | Approved automatically after 2 weeks | |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved | |
| HCHS_SOL:HMB | Approved automatically after 2 weeks | |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks | |
| HVH:DS-CVD-IRB-MDS | Approved automatically after 2 weeks | |
| HVH:HMB-IRB-MDS | Approved automatically after 2 weeks | |
| HyperGEN:DS-CVD-IRB-RD | Approved | |
| HyperGEN:GRU-IRB | Approved | |
| IPF:DS-ILD-IRB-NPU | Disapproved | |
| IPF:DS-LD-IRB-NPU | Disapproved | |
| IPF:DS-PFIB-IRB-NPU | Disapproved | |
| IPF:DS-PUL-ILD-IRB-NPU | Disapproved | |
| IPF:HMB-IRB-NPU | Approved | |
| JHS:DS-FDO-IRB | Approved | |
| JHS:DS-FDO-IRB-NPU | Approved | |
| JHS:HMB-IRB | Approved | |
| JHS:HMB-IRB-NPU | Approved | |
| MESA:HMB | Approved | |
| MESA:HMB-NPU | Approved | |
| MLOF:HMB-PUB | Approved | |
| Mayo_VTE:GRU | Approved | |
| REDS-III_Brazil:GRU-IRB-PUB-COL-NPU | Approved automatically after 2 weeks | |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved | |
| SAGE:DS-LD-IRB-COL | Disapproved | |
| SAPPHIRE_asthma:HMB-COL | Approved | |
| SARP:GRU | Approved | |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved | |
| THRV:DS-CVD-IRB-COL-NPU-RD | Approved automatically after 2 weeks | |
| VAFAR:HMB-IRB | Approved automatically after 2 weeks | |
| VU_AF:GRU-IRB | Approved | |
| WGHS:HMB | Approved automatically after 2 weeks | |
| WHI:HMB-IRB | Approved | |
| WHI:HMB-IRB-NPU | Approved |
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