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Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease

Manuscript ID: 14451

Submitting Author
Dron, Jacqueline
Submitting Author's Email
Authors
Jacqueline S. Dron
Aniruddh P. Patel
Yiyi Zhang
Dimitri J. Maamari
Minxian Wang
Eric Boerwinkle
Alanna C. Morrison
Paul S. de Vries
Myriam Fornage
Lifang Hou
Donald M. Lloyd-Jones
Bruce M. Psaty
Russell P. Tracy
Joshua C. Bis
Ramachandran S. Vasan
Daniel Levy
Nancy Heard-Costa
Stephen S. Rich
Xiuqing Guo
Kent D. Taylor
Richard A. Gibbs
Jerome I. Rotter
Cristen J. Willer
Elizabeth C. Oelsner
Andrew E. Moran
Gina M. Peloso
Pradeep Natarajan
Amit V. Khera
Journal name for most current submission
JAMA Cardiology
Associated TOPMed paper proposal
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" *
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments
I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. *
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. *
Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. *
Yes
I certify that all co-authors have reviewed and approved the manuscript for submission. *
Yes
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.

TOPMed data used in this manuscript

The data set approvals listed here should match the TOPMed data used in this manuscript.

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Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.

Parent Study: Consent Group Review Status Actions
ARIC:HMB-IRB Approved
CARDIA:HMB-IRB Approved automatically after 2 weeks
CHS:HMB-MDS Approved
FHS:HMB-IRB-MDS Approved
MESA:HMB Approved
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