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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Manuscript ID: 6601

Submitting Author
Visscher, Peter
Submitting Author's Email
peter.visscher@uq.edu.au
Authors
Pierrick Wainschtein, Deepti P. Jain, Loic Yengo, Zhili Zheng, TOPMed Anthropometry Working Group, Trans-Omics for Precision Medicine Consortium, L. Adrienne Cupples, Aladdin H. Shadyab, Barbara McKnight, Benjamin M. Shoemaker, Braxton D. Mitchell, Bruce M. Psaty, Charles Kooperberg, Dan Roden, Dawood Darbar, Donna K. Arnett, Elizabeth A. Regan, Eric Boerwinkle, Jerome I. Rotter, Matthew A. Allison, Merry-Lynn N. McDonald, Mina K Chung, Nicholas L. Smith, Patrick T. Ellinor, Ramachandran S. Vasan, Rasika A. Mathias, Stephen S. Rich, Susan R. Heckbert, Susan Redline, Xiuqing Guo, Y.-D Ida Chen, Ching-Ti Liu, Mariza de Andrade, Lisa R. Yanek, Christine M. Albert, Cecelia A. Laurie, Ryan D. Hernandez, Stephen T. McGarvey, Kari E. North, Leslie A. Lange, Bruce S. Weir, Cathy C. Laurie, Jian Yang, Peter M. Visscher
Journal name for most current submission
Nat Genet.
Associated TOPMed paper proposal
Inference on the genetic architecture of height and BMI from whole genome sequence data
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" *
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments
I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. *
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. *
Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. *
Yes
I certify that all co-authors have reviewed and approved the manuscript for submission. *
Yes
Upload all necessary study-specific approval documentation.
_All_approvals_combined.pdf
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I have not
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I have not
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
I have not

TOPMed data used in this manuscript

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Parent Study: Consent Group Review Status
ARIC:DS-CVD-IRB Approved automatically after 2 weeks
ARIC:HMB-IRB Approved automatically after 2 weeks
Amish:HMB-IRB-MDS Approved automatically after 2 weeks
BioMe:HMB-NPU Approved
CARDIA:HMB-IRB Approved automatically after 2 weeks
CCAF:GRU-IRB Approved
CFS:DS-HLBS-IRB-NPU Approved automatically after 2 weeks
CHS:HMB-NPU-MDS Approved
COPDGene:HMB Approved
FHS:HMB-IRB-MDS Approved
FHS:HMB-IRB-NPU-MDS Approved
GOLDN:DS-CVD-IRB Approved
GeneSTAR:DS-CVD-IRB-NPU-MDS Approved
HVH:DS-CVD-IRB-MDS Approved
HVH:HMB-IRB-MDS Approved
HyperGEN:DS-CVD-IRB-RD Approved
HyperGEN:GRU-IRB Approved
MESA:HMB Approved
MESA:HMB-NPU Approved
MGH_AF:DS-AF-IRB-RD Approved automatically after 2 weeks
MGH_AF:HMB-IRB Approved automatically after 2 weeks
Mayo_VTE:GRU Approved
Partners:HMB Approved automatically after 2 weeks
VAFAR:HMB-IRB Approved automatically after 2 weeks
VU_AF:GRU-IRB Approved automatically after 2 weeks
WGHS:HMB Approved automatically after 2 weeks
WHI:HMB-IRB Approved
WHI:HMB-IRB-NPU Approved