Accounting for population structure in genetic studies of cystic fibrosis

Hanley Kingston,1 Adrienne M. Stilp,2 William Gordon,3 Jai Broome,4 Stephanie M. Gogarten,2 Hua Ling,5 John Barnard,6 Shannon Dugan-Perez,7 Patrick T. Ellinor,8,9 Stacey Gabriel,10 Soren Germer,11 Richard A. Gibbs,7 Namrata Gupta,10 Kenneth Rice,2 Albert V. Smith,12 Michael C. Zody,11 The Cystic Fibrosis Genome Project, Scott M. Blackman,13 Garry Cutting,14 Michael R. Knowles,15 Yi-Hui Zhou,16 Margaret Rosenfeld,17,18 Ronald L. Gibson,17,18 Michael Bamshad,3,17,19,20 Alison Fohner,1,21 Elizabeth E. Blue,1,4,20*
Affiliations:
1: Institute for Public Health Genetics, University of Washington, Seattle, Washington, 98195, USA
2: Department of Biostatistics, University of Washington, Seattle, Washington, 98195, USA
3: Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, Washington, 98195, USA.
4: Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, 98195, USA
5: Department of Genetic Medicine, Center for Inherited Disease Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA
6: Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, USA
7: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, 77030, USA.
8: Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02124, USA
9: Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
10: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
11: New York Genome Center, 101 Avenue of the Americas, New York, New York, 10013, USA
12: Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, 48109, USA
13: Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
14: McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
15: Marsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA
16: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, 27797, USA
17: Center for Clinical and Translational Research, Seattle Children’s Hospital, Seattle, Washington, 98105, USA
18: Department of Pediatrics, University of Washington, Seattle, Washington, 98195, USA
19: Department of Genome Sciences, University of Washington, Seattle, Washington, 98195, USA
20: Brotman Baty Institute for Precision Medicine, Seattle, Washington, 98195, USA
21: Department of Epidemiology, University of Washington, Seattle, Washington, 98195, USA
*Correspondence: Elizabeth E. Blue, Email: em27@uw.edu