TOPMed WGS and Omics Summary of Approved Projects
|
Short Name |
Study/Cohort name |
PI |
Populations |
dbGaP ID |
WGS |
RNA-seq |
Methylation |
Metabolomics |
Proteomics |
---|
ATGC |
Asthma Translational Genomics Collaborative |
Burchard Esteban; Williams, L. Keoki; |
|
ATGC dbGaP IDs |
16,494 |
9,290 |
|
|
|
MESA |
Multi-Ethnic Study of Atherosclerosis |
Rotter, Jerome; Rich, Stephen |
Multi-ethnic populations |
phs001416 |
7,107 |
8,903 |
13,286 |
12,800 |
14,200 |
HCHS_SOL |
Hispanic Community Health Study - Study of Latinos |
Kaplan, Robert; North, Kari |
|
phs001395 |
7,834 |
7,733 |
13,000 |
12,226 |
|
ARIC+VTE |
Venous Thromboembolism project |
Boerwinkle, Eric |
20% African American |
phs001211 phs001402 phs000993 |
10,531 |
6,111 |
16,524 |
16,524 |
|
CARDIA |
Cell Disease Whole Genome Sequence Analysis in Early Cerebal Small Vessel Disease |
Fomage, Myriam; Hou Lifang |
|
phs001612 |
3,472 |
6,000 |
9,480 |
12,000 |
12,000 |
MLOF |
My Life, Our Future: Genotyping for Progress in Hemophilia |
Konkle, Barbara; Johnsen, Jill |
|
phs001515 |
5,670 |
4,500 |
|
|
|
PVDOMICS |
Pulmonary Vascular Disease Omics Analyses |
Erzurum, Serpil; Barnard, John; Geraci, Mark; Beck, Gerald; Comhair, Suzy |
|
phs002358 |
1,137 |
4,388 |
1,800 |
|
|
SPIROMICS |
SubPopulations and InteRmediate Outcome Measures In COPD Study |
Meyers, Deborah A |
|
phs001927 |
2,711 |
3,980 |
|
3,417 |
|
FHS |
Framingham Heart Study |
Ramachandran, Vasan S.; Levy, Dan; Heard-Costa, Nancy |
3 generation EA pedigrees |
phs000974 |
7,077 |
5,071 |
4,012 |
6,742 |
5,802 |
Africa6K |
Integrative Genomic Studies of Heart and Blood Related Traits in Africans |
Tishkoff, Sarah; Williams, Scott |
|
phs002194 |
6,392 |
2,934 |
|
|
|
HIPS |
Hemophilia Inhibitor PUPs study |
Brown, Deborah |
|
phs002302 |
25 |
2,596 |
|
|
|
WHI |
Women's Health Initiative |
Kooperberg, Charles; Reiner, Alex |
|
phs001237 |
11,310 |
2,365 |
4,400 |
4,400 |
1,000 |
LTRC |
Lung TIssue Research Consortium |
Silverman, Edwin |
|
phs001662 |
1,541 |
1,548 |
3,041 |
1,548 |
1,548 |
IPF |
Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis |
Schwartz David; Fingerlin, Tasha |
|
phs001607 |
2,883 |
835 |
|
|
|
PharmHU |
The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease |
Boerwinkle, Eric; Sheehan, Vivien; Pace, Betty Sue |
|
phs001466 |
862 |
826 |
|
|
|
COPDGene |
Genetic Epidemiology of COPD |
Silverman, Edwin |
30% African American |
phs000951 phs000946 |
10,829 |
800 |
11,843 |
8,353 |
|
TOPCHeF |
Trans-Omics for Precision Medicine for Congestive Heart Failure |
Taylor, Matthew; Mestroni, Luisa; Graw, Sharon |
|
phs002038 |
839 |
776 |
|
|
|
nuMoM2b-HHS |
nuMoM2b-Heart Health Study |
Blue, Nathan; McNeil, Becky |
|
|
4,341 |
600 |
|
|
|
MDS |
Genomics of Myelodysplastic Syndromes |
Walter, Matthew; Goll, Johannes; Lindsley, R. Coleman; Saber, Wael; Padron, Eric; Miller, Christopher |
|
phs002360 |
473 |
145 |
|
|
|
SCVI |
Stanford Cardiovascular Institute iPSC Biobank Study |
Wu, Joseph; Bustamante, Carlos |
|
phs002338 |
1,163 |
82 |
|
|
|
AA_CAC |
African American Coronary Artery Calcification project |
Taylor, Kent D.; Rotter Jerome |
African American Families |
phs002194 |
1,159 |
|
|
|
|
AFGen |
Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval - Atrial Fibrilation Genetics Consortium |
Ellinor, Patrick |
|
AFGen dbGaP IDs |
12,742 |
|
|
|
|
Amish |
Genetics of Cardiometabolic Health in the Amish |
Mitchell, Braxton D. |
Old Order Amish large extended pedigrees |
phs000956 |
1,120 |
|
|
|
|
PGX_Asthma |
Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma |
Burchard, Esteban; Hernandez, Ryan |
500AA, 500 Puerto Rican, and 500 Mexican of extremely non-responding asthma patients. |
Please see this TOPMed Project's Parent Studies |
1,500 |
|
|
|
|
BAGS |
Barbados Asthma Genetics Study |
Barnes, Kathleen |
African descent Barbados families with >40% of asthmatic members |
phs001143 |
1,085 |
|
|
|
|
BCC-PREG |
The Boston-Colombia Collaborative for Adverse Pregnancy Outcomes |
Gray, Kathryn J.; Casa Romero, Juan P |
|
Please see this TOPMed Project's Parent Studies. |
14,615 |
|
|
|
|
BioMe |
Mount Sinai BioMe Biobank |
Loos, Ruth J.F.; Kenny, Eimear |
|
phs001644 |
11,626 |
|
|
|
|
Boston-Brazil_SCD |
Boston-Brazil Collaborative Study of Sickle Cell Disease |
Sankaran, Vijay G. |
|
phs001599 |
415 |
|
|
|
|
CFS |
Cleveland Family Study |
Redline, Susan |
African American |
phs000954 |
1,300 |
|
|
|
|
CHS |
Cardiovascular Health Study |
Psaty, Bruce; Tracy, Russell |
|
phs001368 |
4,780 |
|
|
|
|
COPDMet |
Plasma and BALF Metabolomics in COPDGene and SPIROMICS |
Bowler, Russell |
|
Please see this TOPMed Project's Parent Studies |
0 |
|
|
|
|
CRA_CAMP |
The Genetic Epidemiology of Asthma in Costa Rica and the Childhood Asthma Management Program |
Weiss, Scott T |
Costa Rica is a special Hispanic population with asthma prevalence at 24% |
phs001726, phs000988 |
6,647 |
|
3,000 |
3,000 |
|
DS_CHD |
Down Syndrome Associated Atrioventricular Septal Defects: New Omic Resources |
Sherman, Stephanie L. |
|
Please see this TOPMed Project's Parent Studies. |
469 |
|
|
|
|
ECLIPSE |
Evaluation of COPD Longitudinally to Idenity Predictive Surrogate Endpoints |
Silverman, Edwin |
|
phs001472 |
2,355 |
|
|
|
|
GEM-OSA |
Genetics, Epigenetics and Metabolomics of OSA subtypes |
Pack, Allan; Carrier, Julie; Magalan, Ulysses; Mignot, Emmanuel; Ayas Najib |
|
Please see this TOPMed Project's Parent Studies. |
3,000 |
|
3,000 |
3,000 |
|
GeneSTAR |
Genetic Studies of Atherosclerosis Risk |
Mathias, Rasika |
African American families, European families |
phs001218 |
1,780 |
|
|
|
|
GenSalt |
Genetic Epidemiology Network of Salt Sensitivity |
He, Jiang |
|
phs001217 |
1,858 |
|
|
|
|
GOLDN |
Genetics of Lipid Lowering Drug and Diet Network |
Amett, Donna K |
European families |
phs001359 |
965 |
|
|
|
|
HLKSCD |
Genetic Variation of Heart, Lung, and Kidney Disease in Sickle Cell Disease: Pre- and Post- Curative Therapies |
DeBaun, Michael; Eapen, Mary; Kang, Guolian; Edwards, Todd; Weiss, Mitch; Estepp, Jeremie; Gordeuk, Victor; Li, Bingshan; Saraf, Santosh |
|
|
1,780 |
|
|
|
|
HyperGEN_GE NOA |
Hypertension Genetic Epidemiology Network and Genetic Epidemiology Network of Arteriopathy |
Amett, Donna K |
African American families |
phs001345 phs001293 |
3,153 |
|
|
|
|
JHS |
Jackson Heart Study |
Carson, April; Raffield, Laura |
African American mixed family and population based |
phs000964 |
3,418 |
|
1,659 |
5,266 |
5,266 |
OMG_SCD |
Outcome Modifying Genes in Sickle Cell Disease |
Ashley-Koch, Allison; Telen, Marilyn |
|
phs001608 |
653 |
|
|
|
|
PCGC_CHD |
Pediatric Cardiac Genomics Consortium's Congenital Heart Disease |
Gelb, Bruce; Seidman, Christine |
|
phs001735 |
3,888 |
|
|
|
|
PROMIS |
Pakistan Risk of Myocardial Infarction Study |
Saleheen, Danish |
South Asian ancestry from Pakistan |
phs001569 |
9,204 |
|
|
|
|
PUSH_SCD |
Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease |
Nekhai, Sergei |
|
phs001682 |
423 |
|
|
|
|
REDS-III_Brazil |
Recipient Epidemiology and Donor Evaluation Study-III |
Custer, Brian; Kelly, Shannon |
Brazilian |
phs001468 |
2,746 |
|
|
|
|
SAFS |
San Antonio Family Studies |
Blangero, John; Curran, Joanne |
Mexican American in SAFHS extended pedigrees |
phs001215 |
1,819 |
|
|
|
|
Samoan |
Samoan Adiposity Study |
McGarvey, Stephen |
Samoan |
phs000972 |
1,295 |
|
|
|
|
Sarcoidosis |
Genetics of Sarcoidosis in African Americans |
Montgomery, Courtney |
African American families |
phs001207 |
1,330 |
|
|
|
|
SARP |
Severe Asthma Research Program |
Meyers, Deborah A |
|
phs001446 |
1,890 |
|
|
|
|
THRV |
Taiwan Study of Hypertension using Rare Variants |
Rotter, Jerome; Chen, Yii-Der Ida |
Taiwan Chinese families |
phs001387 |
2,170 |
|
|
|
|
UNID_CM |
The Genetic Causes of Unexplained Cardiomyopathies |
Seidman, Jonathan; Seidman, Christine |
|
|
779 |
|
|
|
|
Walk-PHaSST |
Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy |
Gladwin, Mark; Zhang, Yingze |
|
phs001514 |
437 |
|
|
|
|