TOPMed Projects and their Parent Studies

Filter this table to display only TOPMed Projects or Parent Studies (see definitions of both). You may also filter by types of sequencing, or use the tabs at the top to filter by start phase.

Notes:
You may encounter phs links that redirect to a dbGaP error page in the table below. If so, this is because the TOPMed dbGaP study webpages do not go live until the study accession is released.

Counts of samples released in parent study-level dbGaP accessions are available in the dbGaP methods documents for freeze4 and freeze5b.

+ denotes Other Sequencing Funding

PI TOPMed Project Short Name Study Name Approx. Sample Size Populations Phases Involved Type of Omics TOPMed Accession #
Taylor, Kent ;
Rotter, Jerome 		AA_CAC AA_CAC African American Coronary Artery Calcification project 1409 African American families
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Ellinor, Patrick ;
 AFGen AFGen Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval - Atrial Fibrillation Genetics Consortium 2799 AF cases all EA
  • 1
  • Other Funding
 WGS Please see this TOPMed Project's Parent Studies.
Tishkoff, Sarah ;
Williams, Scott 		Africa6K Africa6K Integrative Genomic Studies of Heart and Blood Related Traits in Africans 7500DNA
  • 4
 WGS Please see this TOPMed Project's Parent Studies.
Mitchell, Braxton D. ;
 Amish Amish Genetics of Cardiometabolic Health in the Amish 1100 Old Order Amish large extended pedigrees
  • 1
 WGS Please see this TOPMed Project's Parent Studies.
Burchard, Esteban ;
Hakonarson, Hakon ;
Williams, L. Keoki 		ATGC ATGC Asthma Translational Genomics Collaborative 15580 WGS ph3, 3500 RNAseq ph4
  • 3
  • 4
  • 8
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Barnes, Kathleen ;
 BAGS BAGS Barbados Asthma Genetics Study 1100 African descent Barbados families with >40% of asthmatic members
  • 1
 WGS Please see this TOPMed Project's Parent Studies.
Gray, Kathryn J. ;
Casas Romero, Juan P 		BCC-PREG BCC-PREG The Boston-Colombia Collaborative for Adverse Pregnancy Outcomes
  • 7
 WGS Please see this TOPMed Project's Parent Studies.
Loos, Ruth J.F. ;
Kenny, Eimear 		BioMe BioMe Mount Sinai BioMe Biobank 8769 CAD, 2644 COPD
  • 3
 WGS Please see this TOPMed Project's Parent Studies.
Sankaran, Vijay G. ;
 Boston-Brazil_SCD Boston-Brazil_SCD Boston-Brazil Collaborative Study of Sickle Cell Disease 958
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Fornage, Myriam ;
Hou, Lifang 		CARDIA CARDIA Whole Genome Sequence Analysis in Early Cerebral Small Vessel Disease 3622WGS (ph3), 9480Methyl (ph5)
  • 3
  • 5
  • 8
 WGS, Proteomics, Methylomics Please see this TOPMed Project's Parent Studies.
Redline, Susan ;
 CFS CFS Cleveland Family Study 1000 African American
  • 1
 WGS Please see this TOPMed Project's Parent Studies.
Psaty, Bruce ;
Tracy, Russell 		CHS CHS Cardiovascular Health Study 3600
  • 3
 WGS Please see this TOPMed Project's Parent Studies.
Silverman, Edwin ;
 COPD COPD Genetic Epidemiology of COPD 100WGS EOCOPD (ph1), 1885WGS COPDGene (ph1), 7400WGS (ph2), 1000WGS COPDGene (ph3), 800RNASeq COPDGene (ph4), 11,500Methyl COPDGene (ph5) >10,000 non-Hispanic white and African-American, nearly all current and former smokers with and without COPD
  • 1
  • 2
  • 3
  • 4
  • 5
  • Other Funding
 WGS, RNASeq, Methylomics Please see this TOPMed Project's Parent Studies.
Bowler, Russell ;
 COPDMet COPDMet Plasma and BALF Metabolomics in COPDGene and SPIROMICS
  • 7
 Metabolomics Please see this TOPMed Project's Parent Studies.
Weiss, Scott T ;
 CRA_CAMP CRA_CAMP The Genetic Epidemiology of Asthma in Costa Rica and the Childhood Asthma Management Program 1300WGS (ph1), 5319WGS (ph3), 3000Metab (ph5), 3000Methyl (ph5) Costa Rica is a Special Hispanic population with asthma prevalence at 24%
  • 1
  • 3
  • 5
 WGS, Metabolomics, Methylomics Please see this TOPMed Project's Parent Studies.
Sherman, Stephanie L. ;
 DS_CHD DS_CHD Down Syndrome Associated Atrioventricular Septal Defects: New Omic Resources 471WGS (ph5.5)
  • Other Funding
 WGS Please see this TOPMed Project's Parent Studies.
Silverman, Edwin ;
 ECLIPSE ECLIPSE Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints 2400 (ph3)
  • 3
 WGS Please see this TOPMed Project's Parent Studies.
Murabito, Joanne ;
Levy, Daniel ;
Heard-Costa, Nancy ;
O'Connor, George 		FHS FHS Framingham Heart Study 4089WGS (ph1), 1861RNASeq (ph5), 3400Metab (ph5), 1900Methyl (ph5) 3 generation EA pedigrees
  • 1
  • 5
  • Other Funding
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics Please see this TOPMed Project's Parent Studies.
Pack, Allan ;
Carrier, Julie ;
Magalang, Ulysses ;
Mignot, Emmanuel ;
Ayas, Najib 		GEM-OSA GEM-OSA Genetics, Epigenetics and Metabolomics of OSA subtypes
  • 7
 WGS, Metabolomics, Methylomics Please see this TOPMed Project's Parent Studies.
Mathias, Rasika ;
 GeneSTAR GeneSTAR Genetic Studies of Atherosclerosis Risk 1400 African American families, European families
  • 2
  • Other Funding
 WGS Please see this TOPMed Project's Parent Studies.
He, Jiang ;
 GenSalt GenSalt Genetic Epidemiology Network of Salt Sensitivity 1860
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Arnett, Donna K ;
 GOLDN GOLDN Genetics of Lipid Lowering Drugs and Diet Network 967 European families
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Kaplan, Robert ;
North, Kari 		HCHS_SOL HCHS_SOL Hispanic Community Health Study - Study of Latinos 2270
  • 3
 WGS Please see this TOPMed Project's Parent Studies.
Brown, Deborah ;
 HIPS HIPS Hemophilia Inhibitor PUPs study
  • 7
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
DeBaun, Michael ;
Edwards, Todd ;
Eapen, Mary ;
Kang, Guolian ;
Gordeuk, Victor ;
Weiss, Mitch ;
Estepp, Jeremie ;
Li, Bingshan ;
Saraf, Santosh 		HLKSCD HLKSCD Genetic Variation of Heart, Lung, and Kidney Disease in Sickle Cell Disease: Pre- and Post-Curative Therapies
  • 7
 WGS Please see this TOPMed Project's Parent Studies.
Arnett, Donna K ;
 HyperGEN_GENOA HyperGEN_GENOA Hypertension Genetic Epidemiology Network and Genetic Epidemiology Network of Arteriopathy 3161 African American families
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Schwartz, David ;
Fingerlin, Tasha 		IPF IPF Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis 1500
  • 3
 WGS Please see this TOPMed Project's Parent Studies.
Carson, April P. ;
Raffield, Laura 		JHS JHS Jackson Heart Study 3500 African American mixed family and population based
  • 1
 WGS Please see this TOPMed Project's Parent Studies.
Silverman, Edwin ;
 LTRC LTRC Lung Tissue Research Consortium 1548WGS (ph4), 1648RNASeq (ph4), 3196Methyl (ph5)
  • 4
  • 5
  • 8
 WGS, RNASeq, Proteomics, Methylomics Please see this TOPMed Project's Parent Studies.
Walter, Matthew ;
Padron, Eric ;
Miller, Christopher ;
Saber, Wael ;
Lindsley, R. Coleman 		MDS MDS Genomics of Myelodysplastic Syndromes
  • 7
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Rotter, Jerome ;
Rich, Stephen 		MESA MESA Multi-Ethnic Study of Atherosclerosis 4595 multi-ethnic populations
  • 2
  • 6
  • 8
  • Other Funding
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics Please see this TOPMed Project's Parent Studies.
Konkle, Barbara ;
Johnsen, Jill 		MLOF MLOF My Life, Our Future: Genotyping for Progress in Hemophilia 2188 (ph2), 2959 (ph3)
  • 2
  • 3
  • 6
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
;
 MWCCS MWCCS MACS/WIHS COMBINED COHORT STUDY Metabolomics, Proteomics
Blue, Nathan ;
McNeil, Becky 		nuMoM2b-HHS nuMoM2b-HHS nuMoM2b-Heart Health Study
  • 7
 WGS Please see this TOPMed Project's Parent Studies.
Ashley-Koch, Allison ;
Telen, Marilyn 		OMG_SCD OMG_SCD Outcome Modifying Genes in Sickle Cell Disease 675
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Gelb, Bruce ;
Seidman, Christine 		PCGC_CHD PCGC_CHD Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank 3230WGS (ph4), 308RNASeq (ph4)
  • 4
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Burchard, Esteban ;
Hernandez, Ryan 		PGX_Asthma PGX_Asthma Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma 1500 500AA, 500 Puerto Rican, and 500 Mexican of extremely non-responding asthma patients.
  • 1
  • Other Funding
 WGS Please see this TOPMed Project's Parent Studies.
Boerwinkle, Eric ;
Sheehan, Vivien ;
Pace, Betty Sue 		PharmHU PharmHU The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease 1454
  • 2
  • 6
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Saleheen, Danish ;
 PROMIS PROMIS Pakistan Risk of Myocardial Infarction Study 4,211 (WGS ph4), 3,750 (WGS ph+ TOPMed & CCDG co-funded) South Asian ancestry from Pakistan
  • 4
  • Other Funding
 WGS Please see this TOPMed Project's Parent Studies.
Nekhai, Sergei ;
 PUSH_SCD PUSH_SCD Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease 450
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Erzurum, Serpil ;
Beck, Gerald ;
Comhair, Suzy ;
Barnard, John ;
Geraci, Mark 		PVDOMICS PVDOMICS Pulmonary Vascular Disease Omics Analyses
  • 6
  • 8
 WGS, RNASeq, Methylomics Please see this TOPMed Project's Parent Studies.
Custer, Brian ;
Kelly, Shannon 		REDS-III_Brazil REDS-III_Brazil Recipient Epidemiology and Donor Evaluation Study-III 2809 Brazilian
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Blangero, John ;
Curran, Joanne 		SAFS SAFS San Antonio Family Studies 1142 Mexican American in SAFHS extended pedigrees
  • 1
 WGS Please see this TOPMed Project's Parent Studies.
Minster, Ryan L ;
 Samoan Samoan Samoan Adiposity Study 384 (ph1), 912 (ph2) Samoan
  • 1
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Montgomery, Courtney ;
 Sarcoidosis Sarcoidosis Genetics of Sarcoidosis in African Americans 650 African American families
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Meyers, Deborah A ;
 SARP SARP Severe Asthma Research Program 1900
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Wu, Joseph ;
Bustamante, Carlos 		SCVI SCVI Stanford Cardiovascular Institute iPSC Biobank Study 1500WGS, 450RNAseq
  • 5
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Casella, James ;
 SIT_SCD SIT_SCD Silent Infarction Transfusion (SIT) Sickle Cell Disease (SCD)
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Meyers, Deborah A ;
 SPIROMICS SPIROMICS SubPopulations and InteRmediate Outcome Measures In COPD Study 2981 WGS, 5253 RNAseq
  • 4
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Chen, Yii-Der Ida ;
Rotter, Jerome 		THRV THRV Taiwan Study of Hypertension using Rare Variants 2585 Taiwan Chinese families
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Taylor, Matthew ;
Mestroni, Luisa ;
Graw, Sharon 		TOPCHeF TOPCHeF Trans-Omics for Precision Medicine for Congestive Heart Failure 1078RNASeq, 1078WGS
  • 4
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Seidman, Jonathan ;
Seidman, Christine 		UNID_CM UNID_CM The Genetic Causes of Unexplained Cardiomyopathies 1050WGS, 400RNAseq
  • 5
 WGS, RNASeq Please see this TOPMed Project's Parent Studies.
Boerwinkle, Eric ;
 VTE VTE Venous Thromboembolism project 6000
  • 2
  • 6
 WGS, Methylomics Please see this TOPMed Project's Parent Studies.
Gordeuk, Victor ;
Nouraie, Seyed Mehdi ;
Zhang, Yingze 		walk_PHaSST walk_PHaSST Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy 597
  • 2
 WGS Please see this TOPMed Project's Parent Studies.
Kooperberg, Charles ;
Reiner, Alex 		WHI WHI Women's Health Intiative 11,100WGS, 1400RNAseq (ph4), 1400Metab (ph5), 1400Methyl (ph5)
  • 2
  • 4
  • 5
  • 7
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics Please see this TOPMed Project's Parent Studies.
55 studies